Evaluation of Various Techniques for Screening Antimotion Sickness Drugs

Abstract

Hyoscine, diphenhydramine (Benadryl), and N-(dimethylamino-methyl-ethyl)phenothiazine (Lergigan) were given to dogs and to human volunteers, prior to swinging. In addition, these drugs were injd. into dogs before apomorphine admn. Hyoscine, Benadryl, and Lergigan did not increase the vomiting threshold of dogs to apomorphine injn., nor did any of them protect dogs against swing sickness. Hyoscine protected human subjects on the swing but Lergigan and Benadryl were without effect. The lack of correlation between these findings and the effectiveness of these prepns. in air- and seasickness are discussed.