THE PARTICIPATION OF THE LIVER IN THE FORMATION OF POSTHEPARIN ESTERASES

Abstract

The task of the study was to ascertain the participation of the liver in the formation of postheparin esterases. The chronic experiments were carried out on dogs with acrylic vascular cannulas placed into the hepatic vein and vena portae according to London. The modified operation is described in the paper in detail. Heparin was administered in the dose of 200 I.U. per 1 kg body weight into vena portae or one of the hepatic veins. Blood was drawn from these veins at short simultaneous intervals and the activity of postheparin esterases was determined in it. The activity of serum esterases was estimated by the Cherry–Crandall method. Control trials were carried out to study the activity of serum esterases after the administration of saline. The results suggest that postheparin esterases originate in the liver.