Studies on the inhibition of highly purified calf thymus 8S and 7.3S DNA polymeiase α by aphidicolin
Open Access
- 10 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 9 (1), 161-168
- https://doi.org/10.1093/nar/9.1.161
Abstract
On activated DNA aphidicolin competitively inhibits the incorporation of dCMP by both calf thymus DNA polymerase α A2 and C enzymes and inhibits the incorporation of the other three deoxynucleoside monophosphates apparently non-competitively. However, aphidicolin does not inhibit the incorporation of dAMP into poly(dT).oligo(A)10 nor does it inhibit the incorporation of dGMP into poly(dC).oligo(dG)10, but, it does competitively inhibit the incorporation of dTMP into poly(dA).oligo-(dT)10.Keywords
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