Linkage between X‐chromosome markers and manic‐depressive illness
- 1 September 1984
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 70 (3), 282-287
- https://doi.org/10.1111/j.1600-0447.1984.tb01210.x
Abstract
Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age-dependent penetrance. The results are consistent with the hypothesis of X-linkage in major affective illness.Keywords
This publication has 12 references indexed in Scilit:
- X‐linkage and genetic heterogeneity in bipolar‐related major affective illness: reanalysis of linkage dataAnnals of Human Genetics, 1982
- Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive PsychosisThe British Journal of Psychiatry, 1980
- Nonreplication of Linkage to X Chromosome Markers in Bipolar IllnessArchives of General Psychiatry, 1980
- Color Blindness Not Closely Linked to Bipolar IllnessArchives of General Psychiatry, 1979
- The Status of the Gene Map of the Human ChromosomesScience, 1977
- The genetic implications of age-dependent penetrance in manic-depressive illnessJournal of Psychiatric Research, 1977
- Glucose-6-phosphate DehydrogenasePublished by Elsevier ,1974
- Evidence for X-linkage in the transmission of manic-depressive illnessPublished by American Medical Association (AMA) ,1972
- Recombination between Protan and Deutan Genes ; Data on their Relative Positions in Respect of the G6PD LocusNature, 1964
- [42] Glucose-6-phosphate dehydrogenase 6-phosphogluconic dehydrogenaseMethods in Enzymology, 1955