Spanish Delta-Beta-Thalassemia: Hematological Studies and Composition of the Gamma-Chains in Ten Homozygous Patients

Abstract

We report the hematological studies and the composition of the γ-chains of 10 homozygous δβ° -thalassemia patients belonging to 6 families. These patients showed a mild to moderate chronic hemolytic anemia, morphological changes typical of thalas-semia and 100% fetal hemoglobin in their peripheral blood. The homozygous studied synthesized ^Aγ- and ^Gγ-chains in approximately equal amounts, and the fetal hemoglobin with a threonyl residue at position 75 is present and accounts for all the ^Aγproduction.