Molecular structure of r(GCG)d(TATACGC): a DNA–RNA hybrid helix joined to double helical DNA
- 1 October 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 299 (5884), 601-604
- https://doi.org/10.1038/299601a0
Abstract
The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA–RNA hybrid segments surrounding a central region of double helical DNA its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2′ hydroxyl group and cytosine O2. The hybrid–DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.Keywords
This publication has 15 references indexed in Scilit:
- Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA.Proceedings of the National Academy of Sciences, 1982
- The molecular structure of d(ICpCpGpG), a fragment of right-handed double helical A-DNANature, 1982
- Synthesis of the self‐complementary RNA‐DNA hybrid:R(GCG)D(TATACGC)Recueil des Travaux Chimiques des Pays-Bas, 1981
- Crystal structure analysis of a complete turn of B-DNANature, 1980
- Discontinuous DNA ReplicationAnnual Review of Biochemistry, 1980
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- Conformations of nucleosides and nucleotidesProgress in Nuclear Magnetic Resonance Spectroscopy, 1978
- RNA double-helical fragments at atomic resolution: II. The crystal structure of sodium guanylyl-3′,5′-cytidine nonahydrateJournal of Molecular Biology, 1976
- RNA double-helical fragments at atomic resolution: I. The crystal and molecular structure of sodium adenylyl-3′,5′-uridine hexahydrateJournal of Molecular Biology, 1976
- A HYBRID HELIX CONTAINING BOTH DEOXYRIBOSE AND RIBOSE POLYNUCLEOTIDES AND ITS RELATION TO THE TRANSFER OF INFORMATION BETWEEN THE NUCLEIC ACIDSProceedings of the National Academy of Sciences, 1960