Antinociceptive Effect of Intrathecally Administered Serotonin
Open Access
- 31 August 1977
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 47 (3), 269-271
- https://doi.org/10.1097/00000542-197709000-00007
Abstract
The changes in the tail-flick response latency after the intrathecal injection of serotonin was demonstrated. Serotonin, 100 or 200 .mu.g, administered into the rat''s lumbar intrathecal space, produced an analgesic effect for as long as 40 min. Behavioral and morphologic observations after the injections showed no adverse reaction. Serotonin molecules may penetrate the spinal cord tissue and activate the antinociceptive serotonergic pathways.This publication has 7 references indexed in Scilit:
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