Sickle Cell Anemia with Two Adult Hemoglobins—Hb S and Hb GPhiladelphia/S
Open Access
- 1 February 1964
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 23 (2), 206-215
- https://doi.org/10.1182/blood.v23.2.206.206
Abstract
Hemoglobin studies have been presented on a patient with clinically typical sickle cell anemia who was found to possess two major adult hemoglobins, Hb S and hybrid Hb GPhil./S. Four hemoglobins were demonstrated in his mother, Hb A, GPhil., S and GPhil./S, in somewhat unexpected and as yet unexplained proportions. To our knowledge the propositus represents the first description of an individual with a homozygous β chain defect accompanied by a heterozygous α chain abnormality.Keywords
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