Chlorpromazine in Psychiatric Illness

Abstract

THE use of chlorpromazine (10-[3-dimethylaminopropyl]-2-chlorphenothiazine) for the treatment of psychiatric illness was started at the McLean Hospital in September, 1953. At the time of this writing it has been used in 29 cases, which form the basis of this report.The compound is also known as largactil (Poulenc, Limited), or 4560 R.P., and as SKF 2601-A, or Thorazine.‡ It is chemically related to promethazine (Phenergan) and diethazine hydrochloride (Diparcol). It is a Central-nervous-system depressant and has been applied, especially in France, to the treatment of various conditions: manic-depressive psychoses, certain schizophrenias, especially if acute and with excitement or confusion, symptoms . . .