METHODOLOGIC BASIS FOR THE RADIOIMMUNOASSAY OF ENDOGENOUS STEROIDS IN HUMAN PROSTATIC TISSUE
- 1 January 1980
- journal article
- research article
- Vol. 17 (4), 332-336
Abstract
Methods are presented for the accurate radioimmunoassay of tissue dihydrotestosterone, testosterone, estradiol-17.beta., estrone and progesterone that require significantly less time than other methods. Benign prostatic hyperplasia concentrated dihydrotestosterone, estradiol-17.beta. and estrone at levels significantly greater than those found in normal prostate or male plasma. Evidently endocrine factors are important in the etiology of benign prostatic hyperplasia. A wide range of dihydrotestosterone and estrogen levels was found in prostatic adenocarcinoma samples and may reflect the proportion of endocrine-dependent cells in each tumor. Levels of endogenous steroids may provide a rational basis for the selection of endocrine therapy in the treatment of prostatic neoplasia.This publication has 17 references indexed in Scilit:
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