Effect of Metabolites on Accumulation of Citric Acid in Fluoroacetate-poisoned Rats.
- 1 December 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 84 (3), 680-684
- https://doi.org/10.3181/00379727-84-20750
Abstract
In fluoroacetate-poisoned rats, the C4 members of the Krebs cycle further increase the accumulation of citrate in the heart but not in the kidney. C2 members in appropriate doses may completely overcome the fluoroacetate block, a finding which may be of significance in antidotal therapy. In non-poisoned rats both C4 and C2 members of the cycle increase the citrate level in the kidney. The bearing of these findings on the metabolic patterns of various organs is discussed.Keywords
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