Use of 2,5-dichlorophenyl phosphorodichloridothioate in the synthesis of diastereoisomeric dinucleoside phosphorothioates

Abstract

A convenient method for the synthesis, by the phosphotriester approach, of dinucleoside phosphorothioates is illustrated by the preparation and isolation of the pure R_p- and S_p-diastereoisomers of thymidine-3′ thymidine-5′ phosphorothioate (5).