Increased Expression of the c-fosProto-Oncogene in Bone from Patients with Fibrous Dysplasia

Abstract

Fibrous dysplasia is characterized by intense marrow fibrosis and increased rates of bone turnover. The lesions of fibrous dysplasia resemble those described in the long bones of transgenic mice overexpressing the c-fos proto-oncogene. Activating mutations in the α subunit of the stimulatory guanine-nucleotide–binding protein (G_sα) linked to adenylate cyclase have recently been described in bone cells from patients with the McCune–Albright syndrome and fibrous dysplasia.