THE EFFECT OF ESTRIN ADMINISTRATION ON THE REPRODUCTIVE AND BLOOD VASCULAR SYSTEMS: THE THYROID, THYMUS, HYPOPHYSIS, ADRENALS, KIDNEYS, LIVER AND SPLEEN

Abstract

[long dash]In 4 puppies (3 [female][female] and 1 [male]), 7-9 wks. old at the beginning of the experiment, subcutaneous injections of oestrin over a period of 6-17 wks. caused a diminution of the size of the ovaries, an arrest in the development of the follicles and a relative increase in the amount of ovarian stroma, as compared with 2 controls. Marked hyperplasia of the uterine glands (especially the basal glands) followed oestrin injections but no hemorrhagic discharge from the vagina was observed. The hypophysis of the dog receiving [female] sex hormone for 17 wks. was smaller than the hypophysis of the control, and measurements indicate a relatively greater decrease in the anterior than in the posterior lobe. Neither gross nor histopathology was observed in the arteries, heart, liver, spleen, thymus or adrenals after 17 wks. of daily doses of 9 sex hormone.