Urinary Hippuric Acid Excretion as an Index of Toluene Exposure
- 1 March 1967
- journal article
- research article
- Published by Taylor & Francis in Aihaj Journal
- Vol. 28 (2), 129-134
- https://doi.org/10.1080/00028896709342496
Abstract
A simple procedure is described for the analysis of hippuric acid in urine. The sample is extracted with an isopropyl alcohol-diethyl ether mixture, and the hippuric acid is measured in the extractant by ultraviolet spectrophotometry. The excretion of hippuric acid in urine as a metabolic product of toluene was studied in relation to its usefulness in industrial exposures to toluene. Good correlation of hippuric acid content of end-of-shift samples and toluene exposure was found in studies performed in leather-finishing and rubber-coating plants. The hippuric acid test was also found to be useful in measuring the adequacy of cartridge-type respirators in tank painting work.Keywords
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