Studies on the vesicular component of the Auerbach's plexus and the substance P content of the mouse colon in the acute phase of the experimental Trypanosoma cruzi infection

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Abstract
A dramatic reduction in the total number of dense vesicles in Auerbach's plexus of the mouse colon was observed during the acute phase of experimental American Trypanosomiasis (Chagas' disease). A significant decrease in substance P activity of the colon of inoculated animals was also measured. It is suggested that this decrease in substance P activity could be related to the reduction in the number of dense vesicles in Auerbach's plexus.