In our experience acute carbon tetrachloride poisoning is common, and the true diagnosis is missed frequently. The condition in many such cases is diagnosed as uremia due to nephrosis or nephrosclerosis. Several factors probably account for this error: 1. Most cases are now sporadic and nonindustrial. Large industries using the chemical have become aware of its hazards and have applied effective safeguards. Yet undoubtedly huge quantities are purchased by individual persons for cleaning purposes. The potential hazards may be vaguely referred to in fine print on the bottle; however, the patient seldom thinks to associate anuria with exposure to the chemical because of the time interval between exposure and renal symptoms. 2. Intake of alcohol at the time of exposure appears to increase the incidence of acute poisoning and also serves to obscure the cause in the patient's mind. 3. Too many physicians think of carbon tetrachloride poisoning only in