Cardiac myofibrillar ATPase and electrophoretic pattern in experimental heart failure produced by a two-step mechanical overloading in the rat

Abstract

The specific activity of cardiac myofibrillar Ca²⁺ ATPase was significantly lowered in rats with chronic hypertrophy due to aortic stenosis and insufficiency. When studied in polyacrylamide gel electrophoresis, myosin light chains, tropomyosin, and calcium sensitizing factor were all normal.