Tumour-specific antibodies reactive with cell-surface antigens in children with wilms' tumour

Abstract

Tumour-specific antibodies directed against membrane antigens were demonstrated by immuno-fluorescence in three of 45 patients with Wilms' tumour. Antibody capable of collaborating with K cells to kill Wilms' tumour was present in two additional patients. No patient exhibited both membrane immunofluorescence and K-cell collaborating antibody. Of 27 patients with non-renal solid tumours and 52 age-matched controls, none possessed tumour-specific antibody.