Preparation of Optically Pure α-Alkyl β-Hydroxy Nitriles by the Bakers’ Yeast Reduction
- 1 December 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 62 (12), 3851-3855
- https://doi.org/10.1246/bcsj.62.3851
Abstract
The bakers’ yeast reduction of 2-alkyl-3-oxobutyronitrile gave optically pure 2-alkyl-3-hydroxybutyronitriles. Especially 2-phenyl-3-oxobutyronitrile gave only syn diastereomer of 2-phenyl-3-hydroxybutyronitrile in high optical yield.Keywords
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