ON THE TOXICITY OF 9α-FLU0R0HYDR0- CORTISONE AND 9α:-CHLOROHYDRO CORTISONE

Abstract

Experiments on young rats (sensitized by unilateral nephrectomy and 1% NaCl as a drinking fluid) showed that 9[alpha] -fluorohydrocortisone (200 [mu]g/day) and 9[alpha]-chlorohydrocortisone (20 [mu]g/day) produce hypertension, as well as nephrosclerotic and nephritic changes in the remaining kidney, similar to those obtained with DCA (200 [mu]g/day). Mesenteric periarteritis nodosa is produced under these conditions only by DCA and chlorohydrocortisone. Fluorohydrocortisone caused no such vascular changes, but induced a particularly pronounced involution of the lymphatic organs and of the adrenals.