The Effect of Halothane on the Steady-state Levels of High-energy Phosphates in the Neonatal Heart
Open Access
- 1 August 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 67 (2), 231-235
- https://doi.org/10.1097/00000542-198708000-00013
Abstract
The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellular pH mediated the effects of halothane. Steady-state HEP concentrations and intracellular pH were unaffected, despite profound reductions of mechanical performance. The data also suggest that halothane, in the concentrations studied, does not cause significant uncoupling of oxidative phosphorylation.This publication has 8 references indexed in Scilit:
- Mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal Ca2+-activated force by inorganic phosphate.Circulation Research, 1986
- Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.Journal of Biological Chemistry, 1985
- Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria.Journal of Biological Chemistry, 1984
- CALCIUM-TRANSPORT BY CARDIAC SARCOPLASMIC-RETICULUM - MODULATION OF HALOTHANE ACTION BY SUBSTRATE CONCENTRATION AND PH1981
- Lipid composition of sarcolemma, mitochondria and sarcoplasmic reticulum from newborn and adult rabbit cardiac muscleBiochemical Medicine, 1980
- Cytosolic phosphorylation potential.Journal of Biological Chemistry, 1979
- Effect of pressure development on oxygen consumption by isolated rat heartAmerican Journal of Physiology-Legacy Content, 1967
- RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION .1. KINETICS OF OXYGEN UTILIZATION1955