Human Nasal Cells in Continuous Culture. II. Virus Susceptibilities

Abstract

(1) Two strains of epithelial-like cells derived from nasal mucosa were found susceptible to a number of viruses. The fibroblasts which predominated in the early passages of these cell lines were susceptible, although degeneration occurred at a slower rate, to type 4 adenovirus. (2) Cytopathogenic effects were produced by 7 adenoviruses, 3 polio-viruses, 2 ECHO viruses, a Group B Coxsackie virus, herpes simplex, measles, "CA", and "chimp rhinitis" viruses. Titers obtained in the nasal epithelial-like cells are similar to those measured with HeLa cells. Multiplication of certain of these agents was confirmed by titration of passage material. (3) Influenza and mumps viruses and nasal secretions from individuals with common colds were not cytopathogenic.[long dash]Author.