Cytotoxic T cells and mycobacteria
Open Access
- 1 April 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 197 (1), 11-18
- https://doi.org/10.1111/j.1574-6968.2001.tb10575.x
Abstract
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.Keywords
This publication has 35 references indexed in Scilit:
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor DeficiencyScience, 1998
- Differential regulation of IFN‐γ, IL‐10 and inducible nitric oxide synthase in human T cells by cyclic AMP‐dependent signal transduction pathwayImmunology, 1997
- CELLULAR RESPONSES TO INTERFERON-γAnnual Review of Immunology, 1997
- Protection of rats from adjuvant arthritis by immunization with naked dna encoding for mycobacterial heat shock protein 65Arthritis & Rheumatism, 1997
- Report of the Expert Panel IX Vaccines against tuberculosisVaccine, 1996
- The p47phox mouse knock-out model of chronic granulomatous disease.The Journal of Experimental Medicine, 1995
- Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.The Journal of Experimental Medicine, 1994
- Apparent killing of Mycobacterium tuberculosis by cytokine-activated human monocytes can be an artefact of a cytotoxic effect on the monocytesClinical and Experimental Immunology, 1994
- The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosisNature, 1992