5-Hydroxytryptamine releasing activity in culture supernatants of guinea pig lymphocytes
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (3-4), 264-266
- https://doi.org/10.1007/bf01972360
Abstract
5-Hydroxytryptamine (5-HT) is not only involved in anaphylactic reactions but also in delayed-type hypersensitivity (DTH) reactions. Supernatants of cultivated guinea pig spleen lymphocytes were investigated for possessing 5-HT releasing activity. Both fractionated supernatants of mixed lymphocytes unspecifically stimulated by Concanavalin A (Con A) and fractionated supernatants of non-stimulated mixed lymphocytes decrease the 5-HT content of rabbit thrombocytes. Fractions of a molecular weight smaller than 12,500 daltons are more effective than fractions of a higher molecular weight range. The 5-HT releasing activity of the supernatants is discussed in comparison to a cell migration stimulating activity.Keywords
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