The Role of Tubercle Bacilli in Adjuvant Emulsions on Antibody Production to Egg Albumin

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Abstract
Guinea pigs injected with crystalline egg albumin in an emulsion with the Freund adjuvants and containing killed tubercle bacilli showed substantially increased and prolonged antibody levels in their serum measured by the quantitative precipitin reaction as compared with guinea pigs injected with a similar emulsion lacking killed tubercle bacilli. The increased antibody formation was correlated with local granuloma formation and hyperplasia in the regional lymph nodes and spleens of animals receiving the emulsion containing killed tubercle bacilli.