THE USE OF ANTITHYROID DRUGS DURING PREGNANCY*†

Abstract

A study of hyperthyroid-ism in association with pregnancy supported the view that in hyperthyroidism there is an increased incidence of menstrual irregularity, diminished fertility, and a higher than normal rate of fetal loss through miscarriage and stillbirth. Nineteen patients suffering from hyperthyroidism were treated with antithyroid drugs during or shortly before pregnancy. The 22 completed pregnancies yielded 22 living children who showed no evidence of thyroid disturbance or goiter. There were 3 premature deliveries. Sixteen of the mothers remained well after the antithyroid therapy was stopped, whereas 3 required further treatment. It was concluded that pregnancy is beneficial to hyperthyroidism and that antithyroid therapy alone is an effective form of treatment.