LONG-TERM RENAL FUNCTION IN KIDNEY DONORS
- 1 December 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 36 (6), 626-629
- https://doi.org/10.1097/00007890-198336060-00006
Abstract
Patients (20) who underwent uninephrectomy for kidney donation between 1964-1968 participated in a long-term study of the function of the solitary kidney. Mean follow-up after uninephrectomy was 15.8 .+-. 3 yr. One patient with a strong family history of essential hypertension developed de novo mild hypertension. The current creatinine clearance of the donors was 80 .+-. 4 ml/min. The 1 wk, 3-6 mo. and 14-18 yr postuninephrectomy percentages of predonation creatinine clearance were 72 .+-. 3, 76 .+-. 3 and 78 .+-. 2%, respectively. The 24-h urine protein excretion in kidney donors was significantly higher than in controls (141 .+-. 20 mg vs. 74 .+-. 3 mg, respectively, P < 0.0005). Except for 1 donor who may have developed glomerulonephritis, the donors had normal urinary albumin excretion. The cause of the slightly elevated nonalbumin proteinuria is not known. This long-term study of kidney donors shows no adverse effects on the blood pressure and renal function after many years of compensatory hyperfiltration.This publication has 7 references indexed in Scilit:
- Improved outcome following renal transplantation with reduction in the immunosuppression therapy for rejection episodesAmerican Journal Of Medicine, 1980
- STEREOLOGIC STUDY OF GLOMERULAR HYPERTROPHY IN SUB-TOTALLY NEPHRECTOMIZED RAT1978
- The Familial Living Donor in Renal TransplantationJournal of Urology, 1977
- Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male RatsJournal of Gerontology, 1977
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- Donor and Recipient Function 2 to 4 Years After Renal HomotransplantationAnnals of Internal Medicine, 1967
- Renal function in 29 healthy adults before and after nephrectomyJAMA, 1966