Effect of acetylcholine and secretin on medullary collecting duct function in the rat
- 1 January 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 64 (1), 62-65
- https://doi.org/10.1139/y86-009
Abstract
Microcatheterization was used to study the effect of renal arterial infusion of acetylcholine or secretin on medullary collecting duct function in anaesthetized rats. Acetylcholine infusion was associated with natriuresis and increased sodium delivery to, and decreased reabsorption in, the collecting duct. No changes from control function were found with secretin. Renal blood flow was increased with acetylcholine (+82%, p < 0.001), but unchanged with secretin (+15%, nonsignificant). We conclude that acetylcholine natriuresis is due to inhibition of tubular reabsorption of sodium in the medullary collecting duct, as well as in upstream nephron segments. While the latter may be hemodynamically mediated, the former indicates a direct transport effect of the hormone in the terminal nephron segment.This publication has 7 references indexed in Scilit:
- Prostaglandin E2 but not F2 alpha restores the natriuretic response to acetylcholine in indomethacin-treated dogsAmerican Journal of Physiology-Renal Physiology, 1984
- Furosemide action on collecting ducts: effect of prostaglandin synthesis inhibitionAmerican Journal of Physiology-Renal Physiology, 1983
- The effect of a natriuretic atrial extract on renal haemodynamics and urinary excretion in anaesthetized rats.The Journal of Physiology, 1983
- Prostaglandin synthesis inhibition during volume expansion: Collecting duct functionKidney International, 1982
- Studies on the Mechanism of Sodium Excretion during Drug-induced Vasodilatation in the DogJCI Insight, 1982
- Role of medullary hemodynamics in the natriuresis of drug-induced renal vasodilation in the rat.Circulation Research, 1980
- Effects of some vasodilator drugs on transcapillary fluid exchange in renal cortexAmerican Journal of Physiology-Legacy Content, 1976