Effect of cigarette smoking and coffee consumption on apolipoprotein B levels

Abstract

Apolipoprotein B levels were studied in relation to cigarette smoking, coffee and alcohol consumption, physical activity, age and body mass index in 253 men aged 21–61 years. The mean apolipoprotein B level was 7.3 ± 3.2 mg/dl and was higher for smokers compared with non-smokers. Considering the smokers of over 20 cigarettes/day and the non-smokers, this difference reached 12.6 ± 4.3 mg/dl. A significant increase of 7.2 ± 3.5 mg/dl in apolipoprotein B levels was observed in the subjects who drank over 3 cups of coffee/day compared with the remaining subjects, but the increase was only 4.3 ± 3.7 mg/dl when we made a correction for cigarette consumption. Furthermore, for cigarette smoking and coffee consumption, there is apparently an interactive effect with BMI and/or age (vs apolipoprotein B levels). However, with a stepwise selection among explicative variables [age, BMI, smoking (yes/no) and coffee consumption (≤ 3, > 3 cups/day)] and all their interactions of first order, only the interaction between BMI and smoking (BMI^*smoking: b± ES (b) = 0.3029±0.0303), and age and BMI (age^*BMI), are significantly and positively related to serum levels of apolipoprotein B. Thus cigarette smoking, interacting with high BMI, appear related to higher apolipoprotein B levels.