Diseases or Clinical Conditions Associated with Low Leukocyte Alkaline Phosphatase

Abstract

IT has now been well established that the leukocyte alkaline phosphatase in chronic granulocytic leukemia is very low, whereas in morphologically similar cell populations of polycythemia rubra vera with leukemoid features the activity is elevated. Previous studies have also indicated that it is often increased severalfold in a wide variety of clinical states such as pyogenic infections, myocardial infarction, trauma and diabetic acidosis, which presumably have increased adrenocortical activity as one common denominator.^{1 , 2} It has also been demonstrated that increased phosphatase activity results from the administration of ACTH or 17-hydroxycorticosteroids to normal subjects in substantial dosage over a three-day period. . . .