Comparison of aminoglycoside resistance patterns in Japan, Formosa, and Korea, Chile, and the United States
- 1 August 1985
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 28 (2), 282-288
- https://doi.org/10.1128/aac.28.2.282
Abstract
The resistance mechanisms of more than 2,000 aminoglycoside-resistant gram-negative aerobic bacteria were estimated by a method that assigned a biochemical mechanism based on susceptibility to selected aminoglycosides. Strains from hospitals in Japan, Formosa, and Korea (the Far East) were compared with strains from Chile and the United States. Of the strains from Chile, 90% had an aminoglycoside resistance pattern indicative of the 3-N-acetyltransferase [AAC(3)-V] enzyme. Of the strains from the Far East, 78% had susceptibility patterns suggesting the presence of AAC(6') enzymes. In contrast, strains from the United States had a wider variety of resistance mechanisms including 2''-O-adenylyltidyltransferase [ANT(2'')], AAC(3), AAC(6'), and AAC(2'). Reflecting these differences in resistance patterns, the frequencies of resistance to gentamicin, tobramycin, dibekacin, and amikacin in strains from the United States were different from those in strains from the Far East. These differences seem to be correlated with different aminoglycoside usage in the two regions. In the United States, where gentamicin was the most widely used aminoglycoside, 92% of the strains were resistant to gentamicin, 81% were resistant to dibekacin, and 8.8% were resistant to amikacin. In the Far East, dibekacin and kanamycin were widely used in the past and more recently amikacin has been frequently used. Of the strains from this region, 99% were resistant to dibekacin, 85% were resistant to gentamicin, and 35% were resistant to amikacin.This publication has 19 references indexed in Scilit:
- Resistance to Apramycin in Escherichia coli Isolated from Animals: Detection of a Novel Aminoglycoside-modifying EnzymeMicrobiology, 1984
- Outbreaks of hospital infection in southwest England caused by gentamicin-resistant Serratia marcescensJournal of Hospital Infection, 1982
- Enterobacter cloacae: Bacteremia, Epidemiology, and Antibiotic ResistanceClinical Infectious Diseases, 1982
- Aminoglycoside uptake and mode of action—with special reference to streptomycin and gentamicinJournal of Antimicrobial Chemotherapy, 1981
- Occurrence of aminoglycoside-modifying enzymes in resistant strains of enterobacteria and Pseudomonas aeruginosa from several countriesJournal of Antimicrobial Chemotherapy, 1981
- Effect of ionized calcium and soluble magnesium on the predictability of the performance of Mueller-Hinton agar susceptibility testing of Pseudomonas aeruginosa with gentamicinAntimicrobial Agents and Chemotherapy, 1981
- Dissemination of an antibiotic resistance plasmid in hospital patient floraAntimicrobial Agents and Chemotherapy, 1980
- Plasmid-Determined Resistance to Antimicrobial AgentsAnnual Review of Microbiology, 1978
- Chemotherapeutic Evaluation of 5-Episisomicin (Sch 22591), a New Semisynthetic AminoglycosideAntimicrobial Agents and Chemotherapy, 1978
- Effect of Salt Concentration on the Apparent In-Vitro Susceptibility of Pseudomonas and Other Gram-Negative Bacilli to GentamicinThe Journal of Infectious Diseases, 1971