Chloroxymorphamine, an Opioid Receptor Site-Directed Alkylating Agent Having Narcotic Agonist Activity
- 20 April 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 204 (4390), 316-318
- https://doi.org/10.1126/science.86208
Abstract
Chloroxymorphamine, the 6beta-N,N-bis(2-chloroethyl) derivative of oxymorphone, is a potent nonequilibrium narcotic agonist in the longitudinal muscle preparation of guinea pig ileum. The corresponding naltrexone analog,chlornaltrexamine, is a potent nonequilibrium antagonist of morphine. These receptor sitedirected alkylating agents possess considerable potenial as pharmacologic and biochemical probes of apoid receptors.This publication has 6 references indexed in Scilit:
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