FREE RADICALS IN SURVIVING TISSUES

Abstract
Electron spin resonance (ESR) observations on surviving mammalian tissues confirm our earlier observations, based on frozen-dried samples, that tissues contain characteristic concentrations of free radicals of metabolic origin. The new observations show also that the ESR signals exhibited by mammalian tissues appear to originate in the redox enzymes associated with mitochondria. The results suggest that ESR determinations of free radical concentrations in tissues may serve to elucidate the metabolic processes characteristic of certain physiological and pathological conditions.

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