Kaposi's Disease

Abstract
Kaposi's disease is an uncommon but interesting type of tumor, of low-grade malignancy, which may involve any part of the body. It was first described in 1872 by Moritz Kaposi, after whom the disease was named. The growth is also called, more properly, multiple idiopathic hemorrhagic (pigmented) sarcoma. The cutaneous manifestations are well known to the dermatologist, characteristically appearing on the extremities as elevated vascular nodules which become pigmented. Visceral involvement is less frequent and usually follows the cutaneous lesions. It may, however, precede them, and Aegerter and Peale (1) have pointed out that the disease may be primary in the viscera with no evidence of skin involvement. It is the bizarre visceral manifestations of the disease that have aroused particular interest among both clinicians and pathologists. Stats (2) lists the most frequent sites of involvement, excluding the skin in general, as being the glans and preputium penis, the submucosa of the gastro-intestinal tract, the upper and lower respiratory tracts, and the superficial and deep lymph nodes. More unusual locations include serous membranes, spleen, liver, suprarenal glands, myocardium, mesentery, diaphragm, and urinary bladder. A rather comprehensive review of the literature, with particular reference to the visceral manifestations of Kaposi's disease, has recently been made by Tedeschi et al. (3). The case that follows is presented primarily to illustrate some unusual visceral manifestations of the disease, and to add another to the some hundred cases of visceral Kaposi's sarcoma which have already appeared in the literature. Case Report G. M., a 57-year-old Italian male, was admitted to the hospital on Feb. 25, 1947, with a diagnosis of Kaposi's disease. He had been in good health until July 1946, when a mass in the nasopharynx was discovered. Attempts to remove this mass were unsuccessful and resulted in severe hemorrhage. Finally, in November, the lesion was removed and the pathological report was “angiofibrosarcoma of the Kaposi type.” Early in September, several bluish nodular lesions appeared on the palmar surface of the left hand, with similar smaller lesions on the right. In November, lesions developed on the feet, associated with progressive swelling of both legs and of the genitalia. Treatment at the outpatient department of another hospital consisted in roentgen irradiation of the jaw area, several transfusions, and 70 intramuscular injections of non-toxic mustard gas. Despite this treatment, there were progressive generalized weakness, anorexia, and tarry stools. Three weeks before admission ascites developed and a paracentesis was reported to have yielded approximately 8,000 c.c. of fluid. Just before admission there had been hemorrhages of unknown amount from the lower bowel every two or three days. Tenesmus was present. The patient was referred to the hospital for transfusions and further investigation.