The Determination of Cocaine and Its Major Metabolite, Benzoylecgonine, in Postmortem Fluids and Tissues by Computerized Gas Chromatography/Mass Spectrometry

Abstract
An analytical procedure for the simultaneous determination of both cocaine and benzoylecgonine in postmortem fluid and tissue samples has been developed by using computerized gas chromatography/mass spectrometry and gas chromatography using a nitrogen/phosphorus (N/P) detector. Both methods are accurate and sensitive and allow the determination of tissue concentrations of cocaine and benzoylecgonine as low as 0.015 microgram/mL.