Bilateral loculations in the mandibular rami and erosion of the coronoid processes of the mandible of a patient with Melnick-Needles syndrome (osteodysplasty) were found. The jaws of 4 other individuals with the same disorder were examined for similar changes. The coronoid process of the mandible was grossly hypoplastic in all patients, and the rami were markedly abbreviated. In 4 of the 5 patients the angle was rounded. In 3 of 5 patients, loculations of unknown nature were found in the mandibular rami. Several patients exhibited impacted molar teeth.