Chronic Renal Failure and Bladder Augmentation: Stomach Versus Sigmoid Colon in the Canine Model

Abstract

A canine model for chronic renal failure and bladder augmentation with a segment of stomach or sigmoid colon (or control) was developed to evaluate the possible benefit of net chloride ion excretion noted in an earlier canine model for gastrocystoplasty. Gastrocystoplasty animals behaved similar to control animals relative to the sigmoid cystoplasty animals, tolerated significantly greater acid loading, did not have hyperchloremia with acidosis and had less weight loss with acidosis. Gastrocystoplasty seems to be superior to sigmoid cystoplasty in the azotemic canine.