Isolation of a low-molecular-weight antibacterial system from human amniotic fluid
- 1 November 1976
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 14 (5), 1156-1166
- https://doi.org/10.1128/iai.14.5.1156-1166.1976
Abstract
A low-molecular-weight antibacterial system has been isolated from human amniotic fluid. The bacterial inhibitor requires the metal cation zinc and a peptide with a molecular weight of 630. The peptide component was purified using ultrafiltration, gel filtration, and ion-exchange chromatography. It can be inactivated by digestion with carboxypeptidase. The amino acid composition of the peptide is: 3 glutamine-glutamic acid, 2 glycine, and 1 lysine. Removal of zinc from the peptide has been shown to remove bacterial inhibitory activity.This publication has 32 references indexed in Scilit:
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