Human Studies on the Biological Actions of IGF-1. Evidence Suggesting that Human Fetal and Postnatal Epiphyseal Cartilage is a Target Tissue for IGF-1 Action
- 1 January 1993
- journal article
- review article
- Published by Walter de Gruyter GmbH in Journal of Pediatric Endocrinology and Metabolism
- Vol. 6 (3-4), 257-262
- https://doi.org/10.1515/jpem.1993.6.3-4.257
Abstract
Recent data show that in humans IGF-1 has insulin-like anabolic and growth promoting effects. However, the plasma levels at which IGF-1 exerts these effects differ. IGF-1 plasma levels similar to those in normal children and adults have a growth promoting effect, but higher levels are necessary for IGF-1 to exert insulin-like anabolic effects, and hypoglycemia is a potential risk. Longitudinal bone growth results from the proliferation and differentiation of chondrocytes in epiphyseal cartilage. We present our data from cultured human epiphyseal chondrocytes, which suggest that epiphyseal cartilage may be a target tissue for IGF-1 action during human fetal and postnatal development.Keywords
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