Timolol Reduces the Standing Potential of the Eye

Abstract

Timolol, applied as an 0.5% ophthalmic solution, reduces the light insensitive component of the electro-oculogram by about 40%. This observation suggests that the ocular hypotensive effect of this drug is due to a reduction of the active transport mechanism of the ciliary epithelium, and that these cells are under adrenergic nervous control.