SPONGIFORM ENCEPHALOPATHY OF ROCKY MOUNTAIN ELK

Abstract

A disease with striking clinical and pathologic similarities to the spongiform encephalopathies is described in 6 Rocky Mountain elk (C. elaphus nelsoni) maintained in wildlife facilities in Colorado and Wyoming [USA]. Clinical signs included behavioral alterations and progressive weight loss over a period of weeks or months. Consistent microscopic lesions were limited to the CNS and characterized by widespread spongiform transformation in the neuropil, intracytoplasmic vacuoles in neuronal perikaryons and astrocytic hypertrophy and hyperplasia.