Untersuchungen über die Wirkung von Pharmaka auf Tiere verschiedenen Alters

Abstract

The normal food consumption was tested on male rats of 2 1/2, 5, 11 and 26-30 months. Each group consisted of 8-10 animals and was tested during 10 days. A special food container was constructed which allowed exact measurements of the daily food consumption. The influence of amphetamine (Benzedrine) and of Preludin (phenmetrazine hydro-chloride) was tested. Normal food uptake was highest in the old group. Calculated per unit body weight the 2 1/2 month-old rats consume most, but 27-30-month-old rats consumed more than 5- and 11-month-old animals. Amphetamine, 2 mg/kg, subcutaneously, decreased the food consumption of the old rats by about 20% and also their body weight decreased. The younger animals were not influenced. Preludin 15 mg/kg, subcutaneously, decreased the food consumption in 27-30-month-old rats by about 35% and that of 11-month-old animals by about 12%. The body weight decreased in both groups.