Inhibition of DOPA Decarboxylase by Aromatic Acids Associated with Phenylpyruvic Oligophrenia
- 1 December 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 93 (3), 413-414
- https://doi.org/10.3181/00379727-93-22773
Abstract
Phenylpyruvic acid, phenyllactic acid and phenylacetic acid inhibit beef adrenal medulla DOPA decarboxylase. Phenylalanine had no effect. These data suggest an explanation for low epinephrine plasma levels observed in patients afflicted with phenylpyruvic oligophrenia in that these aromatic acids, which accumulate as a result of the biochemical lesion, may inhibit synthesis of epinephrine in the adrenal gland.Keywords
This publication has 4 references indexed in Scilit:
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- The Concentration of Adrenaline in Human Plasma and its Relation to Mental ActivityJournal of Mental Science, 1955
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