THE PLASMA REMOVAL OF INDOCYANINE GREEN AND SULFOBROMOPHTHALEIN: EFFECT OF DOSAGE AND BLOCKING AGENTS
Open Access
- 1 September 1961
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 40 (9), 1648-1655
- https://doi.org/10.1172/jci104387
Abstract
It has been shown that the removal of indocyanine green from dog plasma is an inverse function of the initial single dose. A maximal initial transfer capacity for hepatic uptake after a single dose of dye has been found. The mechanism whereby several dyes, taken up by the liver, compete with each other or block each other appears to be molecular competitive inhibition. The data do not support the concept that some of these dyes are, a priori, taken up selectively. It has been shown that bilirubin blocks the removal of indocyanine green as do the dyes, and that the rate of removal of indocyanine green in Gunn rats is dependent on the degree of bilirubinemia.This publication has 15 references indexed in Scilit:
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