Testicular Function after Combined Chemotherapy for Metastatic Testicular Cancer

Abstract

In 10 patients cured for metastatic testicular cancer by combination chemotherapy, serum hormone levels and serum agglutinating antibodies were analyzed 12-35 mo. after discontinuation of the treatment. Together with these examinations, sperm analysis was done. All patients had increased levels of follicle stimulating hormone (FSH). Serum testosterone was usually in the lower part of the normal range (below 20 nmol/l). In 8 patients the serum agglutinating antibodies were normal, while 2 patients had increased levels. In all patients azoospermia was observed, indicating long-lasting infertility in patients in whom testicular cancer was treated by combination chemotherapy. The possible importance of cryopreservation prior to start of chemotherapy is discussed.