Mechanism of follicular antigen trapping. Migration of antigen-antibody complexes from marginal zone towards follicle centres.
- 1 November 1973
- journal article
- Vol. 25 (5), 847-52
Abstract
In spleens of normal mice transport of immune complexes takes place from the marginal zone towards the follicle centres. Some hours after an injection with paratyphoid vaccine the marginal zone in the spleen of mice shows a significant lack of lymphoid cells. In such mice trapping of immune complexes in lymphoid follicles is severely inhibited or delayed. These results strongly support the idea that lymphoid cells carry immune complexes from the marginal zone towards follicle centres.This publication has 8 references indexed in Scilit:
- The vascular pathways in the white pulp of the rabbit spleen.1972
- A defect of B-lymphocyte transport of aggregated HGG into germinal centres in NZB and NZB x NZW F 1 hybrid mice.1972
- Antigens in the spleen. The non-specificity of the follicles in the process of antigen trapping and the role of antibody.1972
- Lymphocyte-mediated Transport of Aggregated Human γ-Globulin into Germinal Centre Areas of Normal Mouse SpleenNature, 1970
- A morphological and histochemical study of the primary and secondary immune responses in the rat spleenJournal of Anatomy, 1967
- LOCALIZATION OF NON-MICROBIAL ANTIGENS IN DRAINING LYMPH NODES OF TOLERANT NORMAL AND PRIMED RABBITS1967
- DISTRIBUTION OF ANTIGENIC AND NONANTIGENIC COMPOUNDS WITHIN DRAINING LYMPH NODES1966
- HISTOPHYSIOLOGY OF ANTIBODY RESPONSE .1. HISTOGENESIS OF PLASMA CELL REACTION IN RABBIT SPLEEN1963