Effects of Guanethidine on Tri-Iodothyronine-Induced Hyperthyroidism in Man

Abstract

ALTHOUGH observations in laboratory animals have suggested that there is an intimate relation between many of the manifestations of drug-induced hyperthyroidism and the activity of the sympathetic nervous system, the existence of such a relation has not been clearly established. In the presence of hyperthyroidism the hemodynamic responses to injected catechol amines are augmented.¹ The studies of Brewster et al.² have demonstrated that total epidural blockade reverses some of the hemodynamic and metabolic changes characteristic of hyperthyroidism induced in dogs by feeding of thyroid substance. In clinical practice reserpine has been used successfully in the treatment of some of the . . .