Recent Developments in Pathophysiologic Studies of the Renin-Angiotensin System

Abstract

THE role of the kidney in the regulation of blood pressure through the mediation of renin was first suggested by the classic experiments of Goldblatt.¹ Although there was considerable initial enthusiasm that such a mechanism might provide a clue to the etiology of human hypertension, a series of confusing experiments in animal models, as well as an inability to define the components of this system with methods then available, lessened interest in renin among clinicians. Within recent years, through the efforts of a number of investigative groups, the interrelations between the multiple components of this system have been elucidated. The . . .