Estrogen and Substrate Metabolism
- 1 January 2000
- journal article
- review article
- Published by Springer Nature in Sports Medicine
- Vol. 29 (4), 221-227
- https://doi.org/10.2165/00007256-200029040-00001
Abstract
The increasing number of females participating in physical activity has heightened our awareness of changes in the menstrual cycle which often accompany physical activity. As such, there has been a considerable amount of research investigating the relationships between menstrual cycle changes and bone mineral density, performance, ventilation and substrate metabolism. A number of researchers have concluded that there may be enhanced fat metabolism in eumenorrhoeic versus amenorrhoeic females, or in the follicular phase versus the luteal phase of the menstrual cycle, due to the theoretical estrogen level in eumenorrhoeic versus amenorrhoeic females or the luteal phase versus the follicular phase. However, a definite relationship between resting estrogen level and substrate metabolism has not been clearly established. In addition, the mechanisms which may be responsible for the effect of estrogen on substrate metabolism have not been addressed. It appears that the effects of estrogen on metabolism may be via the effect of estrogen on glucogenic hormones or lipolytic enzymes. Therefore, the primary purpose of this review is to explore the effects of estrogen on substrate metabolism. Menstrual cycle physiology and possible mechanisms for the effects of estrogen on metabolism, as well as previous research on estrogen and metabolism in rats and humans, will be discussed.Keywords
This publication has 42 references indexed in Scilit:
- Serum Lipid Levels and Steroidal Hormones in Women Runners With Irregular MensesCanadian Journal of Applied Physiology, 1997
- Effects of Exercise Training on Plasma Lipids and LipoproteinsExercise and Sport Sciences Reviews, 1994
- Physiological responses to submaximal exercise at the mid‐follicular, ovulatory and mid‐luteal phases of the menstrual cycleScandinavian Journal of Medicine & Science in Sports, 1991
- Effects of the Menstrual Cycle on Resting Muscle Glycogen ContentHormone and Metabolic Research, 1990
- The Menstrual Cycle and Exercise: Performance, Muscle Glycogen, and Substrate ResponsesInternational Journal of Sports Medicine, 1989
- Lipid Metabolism and Coagulation During the Normal Menstrual CycleHormone and Metabolic Research, 1989
- The Effects of Ovarian Hormones on Glucose and Fatty Acid Oxidation during Exercise in Female Ovariectomized RatsHormone and Metabolic Research, 1988
- Mechanism of oestrogen and progesterone effects on lipid and carbohydrate metabolism: alteration in the insulin: glucagon molar ratio and hepatic enzyme activityEuropean Journal of Clinical Investigation, 1977
- The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue.JCI Insight, 1975
- Sex Steroid Influence on Hepatic Gluconeogenesis and Glycogen Formation1Endocrinology, 1973